Kuo Liu, Hengwei Jin, Muxue Tang, Shaohua Zhang, Xueying Tian, Mingjun Zhang, Ximeng Han, Xiuxiu Liu, Juan Tang, Wenjuan Pu, Yan Li, Lingjuan He, Zhongzhou Yang, K. O. Lui, Bin Zhou
{"title":"Lineage tracing clarifies the cellular origin of tissue-resident macrophages in the developing heart","authors":"Kuo Liu, Hengwei Jin, Muxue Tang, Shaohua Zhang, Xueying Tian, Mingjun Zhang, Ximeng Han, Xiuxiu Liu, Juan Tang, Wenjuan Pu, Yan Li, Lingjuan He, Zhongzhou Yang, K. O. Lui, Bin Zhou","doi":"10.1083/jcb.202108093","DOIUrl":null,"url":null,"abstract":"Liu et al. reassess the cellular origin of tissue-resident macrophages in the developing heart. By generating new genetic tools, they reveal that cardiac macrophages are mainly derived from the hemogenic endothelium of yolk sac and aorta-gonad-mesonephros but not from the endocardium.","PeriodicalId":343306,"journal":{"name":"The Journal of Cell Biology","volume":"4 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2022-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"7","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of Cell Biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1083/jcb.202108093","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 7
Abstract
Liu et al. reassess the cellular origin of tissue-resident macrophages in the developing heart. By generating new genetic tools, they reveal that cardiac macrophages are mainly derived from the hemogenic endothelium of yolk sac and aorta-gonad-mesonephros but not from the endocardium.