CHAPTER 6. Impact of Nanoparticle–Protein Interactions on Biological Assays

Abstract

Protein coronas on nanoparticles not only bring a wide range of applications, but also show various limitations. When nanoparticles come into contact with biological fluids, a range of biomolecules, including lipids and proteins, adsorb on the surfaces of the nanoparticles and form protein coronas. Thus, in this chapter, we will review various factors involved in the interactions of nanoparticles and protein coronas, and the pros and cons of these interactions in reference to biological impacts and assays.