Antiobesity effect of Lipovedic formulation in rats fed on atherogenic diet

Abstract

Objective: To study the antiobesity effect of Lipovedic, a polyherbal formulation in rats fed on atherogenic diet. Methods: Animals were fed atherogenic diet for 40 days. Lipovedic was administered in a dose of 900 mg/kg, p.o., twice a day to the drug treatment groups. The effect of Lipovedic on following parameters was recorded – body weight, body temperature (rectal temperature), locomotor activity, various biochemical parameters like serum glucose, total cholesterol and triglyceride levels, and organ and fat pad weight. Results: There was a significant reduction in body weight, organ and fat pad weight, increase in body temperature, locomotor activity and significant reduction in serum total cholesterol and serum triglyceride levels after treatment with Lipovedic in atherogenic diet fed rats. Conclusion: Lipovedic, a polyherbal formulation exhibited antiobesity effect in atherogenic fed rats.