A spectrum of severity and prevalence of malignant hyperthermia in anesthetized patients with inhalational anesthetic.

Abstract

Introduction: Malignant hyperthermia (MH) or hyperpyrexia is a pharmacogenetic syndrome of skeletal muscles caused by volatile anesthetics such as halothane and depolarized muscle relaxant suxamethonium. The prevalence of MH in Islamabad has not been explored. Methodology: This was a retrospective study on the severity and prevalence of MH in anesthetized patients with inhalational anesthetics Clinical data from the previous years, i.e. from June 2020 to June 2021, from eight tertiary care hospitals in Islamabad was collected. Results: Out of 40,900 patients discharged from these hospitals under general anesthesia, only 07 patients were diagnosed with MH due to anesthesia. MH is associated with gender; in our study, more incidence was observed in males than females. Of the seven patients with MH, four (57.14%) were males, and three (42.86%) were females. The prevalence rate of MH was 0.018% due to anesthesia in surgical patients which is approximately 1 per 5842 cases. Conclusion: This research study concluded that the prevalence rate of MH in Islamabad is 0.018%. The prevalence rate for males is slightly higher than for females. According to this statement, the total number of male patients who got MH was four, and females were three out of 40900 surgical cases under general anesthesia in a specific year of duration. The prevalence of MH due to anesthesia in surgical patients treated in Islamabad hospitals is approximately 1 per 5842 cases. MH risk in males is significantly higher than in females.