ANALYSIS OF THE FREQUENCY OF OCCURRENCE OF MOLECULAR GENETIC MARKERS OF PREDISPOSITION TO CARDIOVASCULAR PATHOLOGY IN ATHLETES

A. S. Lyulchenko
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Abstract

For decades, cardiovascular diseases have been the leading cause of disability and death worldwide. Among athletes, the risk of cardiovascular disease increases significantly due to extreme physical exertion. Genotyping of the DNA samples of athletes and the control group based on the selected candidate genes for the pathology of the cardiovascular system was carried out. Carriers of unfavorable genotypes that significantly increase the risk of thrombosis were identified in the formed groups: dangerous mutations of blood clotting factors II and V were detected in 3.2 % of gymnasts and 17.1% of representatives of fire and rescue sports.
运动员心血管疾病易感性分子遗传标记发生频率分析
几十年来,心血管疾病一直是全世界致残和死亡的主要原因。在运动员中,由于极度体力消耗,心血管疾病的风险显著增加。根据选择的心血管系统病理候选基因,对运动员和对照组的DNA样本进行基因分型。在形成的人群中发现了明显增加血栓形成风险的不利基因型携带者:3.2%的体操运动员和17.1%的消防救援运动代表中检测到凝血因子II和V的危险突变。
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