Sự thiếu vitamin D ảnh hưởng sức khỏe và một số bệnh tật

Abstract

Vitamin D deficiency are increasing at a global level, and they are associated with increased risk of various diseases. In Vietnam, the prevalence of Vitamin D deficiency ranged from 20% to 46%, up to 81.6% in the population in South Asia, 69.5% in the US and 86.4% in European countries. Vitamin D is one of the essential nutrients to sustain the human health. As a member of the steroid hormone family, it has a classic role in regulating metabolism of calcium and a non-classic role in affecting cell proliferation and differentiation. With the finding of the vitamin D receptor in nearly every tissues and the more recent discovery of thousands of VDR binding sites throughout the genome controlling hundreds of genes, the interest in vitamin D and its impact on multiple biologic. Therefore, vitamin D has many effects include xenobiotic detoxification, oxidative stress reduction, neuroprotective functions, antimicrobial defense, immunoregulation, anti-inflammatory, anticancer actions, and cardiovascular benefits. Thus, Vitamin D deficiency is closely associated with common chronic diseases such as bone metabolic disorders, tumors, cardiovascular diseases, and diabetes. Key words: Vitamin D deficiency, health, diseases.