Multi-analyte detection handheld analyzer for point-of-care application with disposable biochips

Proceedings of IEEE Sensors 2003 (IEEE Cat. No.03CH37498) Pub Date : 2003-10-22 DOI:10.1109/ICSENS.2003.1279011

M. Dutta, L. Ramasamy, Xiaoshan Zhu, J. Do, C. Gao, C. Hong, A. Puntambekar, J. Han, Se Hwan Lee, R. Trichur, Jin-Woo Choi, J. Nevin, C. Ahn, S. Chilukuru

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引用次数: 3

Abstract

In this work, we present the development of a handheld analyzer for actuation and sensing control of a disposable biochip for point-of-care monitoring of clinically relevant parameters. The disposable biochip has integrated on-chip air bursting detonators for fluid driving linked to a smart passive microfluidic system and an array of biosensors capable of simultaneously monitoring oxygen, glucose and lactate concentrations in human blood. The handheld analyzer houses the SMT (surface mount technology) based electronics system for providing the driving signals to the air bursting detonators and to monitor the analyte signals from the biosensors. We have designed, tested and characterized the analyzer using the disposable biochips to test analytes from human blood. The analyzer developed in this work is /spl sim/ 5.25" /spl times/ 3.5" times; 1.5" and is currently the smallest unit capable of multi-parameter detection from human blood samples.

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多分析物检测手持分析仪点护理应用与一次性生物芯片

在这项工作中，我们提出了一种手持式分析仪的开发，用于一次性生物芯片的驱动和传感控制，用于临床相关参数的即时监测。一次性生物芯片集成了芯片上的空气爆破雷管，用于流体驱动，与智能被动微流体系统和一系列生物传感器相连接，能够同时监测人体血液中的氧气、葡萄糖和乳酸浓度。手持式分析仪装有基于SMT(表面贴装技术)的电子系统，用于向空气爆破雷管提供驱动信号，并监测来自生物传感器的分析物信号。我们使用一次性生物芯片设计，测试和表征了分析仪，以测试来自人类血液的分析物。本工作研制的分析仪为/spl sim/ 5.25”/spl times/ 3.5”倍;1.5英寸，是目前能够从人类血液样本中进行多参数检测的最小单位。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Proceedings of IEEE Sensors 2003 (IEEE Cat. No.03CH37498)

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