Characteristics of centenarian studies and variables related to longevity: A narrative review

Abstract

Studying centenarians requires a “positive biology” approach, where rather than focusing on disease, the research aims to understand the causes of positive phenotypes and explain biological mechanisms of health and longevity. This review outlines the characteristics of the key centenarian studies. Variables that may relate to the longevity of these oldest old are also described, including cardiovascular health, cognitive function, physical ability, mental and cognitive health, personality, and the social circumstances of the centenarian.