Ameliorative Effects of Curcumin-Zinc Oxide Nanoparticles Conjugate on Cyclophosphamide-Induced Infertility in Male Rats

Zagazig Veterinary Journal Pub Date : 2019-03-13 DOI:10.21608/ZVJZ.2019.28657

Khalifa E. Ahmad, R. A. El-Aziz, Mahran M. Abd El-Emam

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Abstract

The present study aimed to investigate the ameliorative effects of Curcumin-ZnO NPs conjugate on testicular tissue damage induced by the anticancer cyclophosphamide. Seventy adult male albino rats weighing 150±15g were used in this study; 10 of them served as a control and 60 rats were intraperitoneal injected with cyclophosphamide at a dose of 30 mg/kg BW every other alternative day for 14 days. They were subdivided into CP group, CP + Curcumin NPs (15 mg/kg B.W), CP + ZnO NPs (10 mg/kg B.W), CP + Curcumin-ZnO NPs conjugate (10 mg/kg B.W), CP + Curcumin-ZnO NPs conjugate (15 mg/kg BW) and CP + Curcumin-ZnO NPs conjugate (20 mg/kg B.W) group. All treatments were given for 30 days. The results reported that curcumin- ZnO NPs conjugate treatment at doses of 15 and 20 mg/kg BW exhibited significant increase in sperm motility percent, sperm count, testicular antioxidant enzymes activities and serum testosterone and FSH levels and significant decrease in sperm abnormalities percent compared to cyclophosphamide treated rats. It was concluded that curcumin- ZnO NPs conjugate at doses of 15 and 20 mg/kg B.W ameliorate the testicular tissue damage induced by the anticancer cyclophosphamide.

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姜黄素氧化锌纳米粒子偶联物对环磷酰胺诱导雄性大鼠不育的改善作用

本研究旨在探讨姜黄素- zno NPs偶联物对抗癌环磷酰胺致睾丸组织损伤的改善作用。实验选用体重150±15g的成年雄性白化大鼠70只;其中10只作为对照组，60只大鼠每隔一天腹腔注射环磷酰胺30 mg/kg BW，连续14天。将其分为CP组、CP +姜黄素NPs (15 mg/kg B.W)、CP + ZnO NPs (10 mg/kg B.W)、CP +姜黄素-ZnO NPs偶联(10 mg/kg B.W)、CP +姜黄素-ZnO NPs偶联(15 mg/kg BW)和CP +姜黄素-ZnO NPs偶联(20 mg/kg B.W)组。所有治疗疗程均为30天。结果表明，与环磷酰胺处理大鼠相比，姜黄素- ZnO NPs偶联剂15和20 mg/kg BW处理大鼠精子活动率、精子数量、睾丸抗氧化酶活性、血清睾酮和卵泡刺激素水平显著增加，精子异常率显著降低。结果表明，姜黄素- ZnO NPs在15和20 mg/kg B.W剂量下可改善抗癌环磷酰胺引起的睾丸组织损伤。

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Zagazig Veterinary Journal

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