Collapsing glomerulopathy with IgA nephropathy

Abstract

Primary IgA nephropathy (IgAN) is the most common primary glomerulonephritis globally. Its epidemiology, clinical presentation, histology, and prognosis vary widely. Focal segmental glomerulosclerosis is frequently seen in IgAN and is an indicator of poor prognosis. Collapsing glomerulopathy (CG) associated with IgAN is rarely seen, and its treatment and prognosis are largely unknown. We present here, two male patients presented with renal failure and nephrotic syndrome. Renal biopsy in the first patient revealed CG with IgAN with significant interstitial fibrosis and tubular atrophy and hence treated with supportive therapy. In the second patient, concomitant CG and IgAN were diagnosed and started on oral steroids and had partial improvement.