Simulation Studies Based on the Pharmacokinetic Model of Diabetes Mellitus

Abstract

This study illustrates that the overall model based on pharmacokinetic diagrams of insulin and glucose is able to follow the dynamics of glucose in Type I diabetes. Both models are capable of predicting the blood glucose and insulin levels, total glucose uptake and the renal glucose excretion. A four-daily dose and continuous injection of insulin therapy has been used for suppressing and normalizing the change of blood glucose. The results show that continuous injection has more precise control than the traditional regime of daily injections.