PERIPHERAL VASCULAR TONE IN YOUNG RESIDENTS OF THE EUROPEAN NORTH WITH ENDOTHELIN -1 GENE POLYMORPHISM LYS198ASN

Abstract

The frequency of the endothelin-1 (EDN1) - Lys198Asn (rs5370) gene polymorphism in the population of the young population of the city of Arkhangelsk and its possible relationship with the indicators of peripheral vasoconstriction were studied. The population of young healthy ethnic Russians aged 18-22 years, from the moment of birth, living in the territory of the Arkhangelsk region was examined. Genotyping was performed by polymerase chain reaction, and the level of EDN1 was determined by enzyme immunoassay. In the course of the study, it was found that individuals with the GG genotype make up 63%, heterozygotes GT-31%, homozygotes for the mutant allele T-6%. The concentration of endothelin-1, one of the main factors affecting the normal functioning of the endothelium and whose role in the development of cardiovascular pathology has been proven by numerous studies, was 0.45 fmol / ml in the group with the GG genotype, and in the group of carriers of the mutant allele (GT+TT), was significantly higher by 27.4% (p=0.04). When analyzing the main indicators of peripheral hemodynamics in individuals with different genotypes, no statistically significant differences were found, but an increase in all indicators was observed when carrying the T allele. It can be assumed that individuals with the GT and TT genotypes are at risk of developing cardiovascular pathology. In addition, 23.6% of the young population had a hypertonic reaction to the load. In the present work, no significant differences in central and peripheral hemodynamic parameters were found in individuals with different genotypes for the EDN - 1 gene Lys198Asn polymorphism, which may be due to the small number of examined patients, so it is necessary to conduct further large-scale population studies.