Simple and efficient synthesis of 2,4,5-triarylsubstituted imidazole derivatives via a multicomponent reaction using microwave irradiation

Abstract

The simple and efficient procedure for a four-component condensation of benzil, aromatic aldehydes, ammonium acetate and 8-hydroxy-7-iodoquinoline-5-sulfonic acid (HISA) as the catalyst under microwave irradiation in mild reaction conditions to synthesis some of 2,4,5-triarylsubstituted imidazole derivatives. The present method is excellent yields, eco-friendly, shorter reaction time, inexpensive and readily available catalyst.The simple and efficient procedure for a four-component condensation of benzil, aromatic aldehydes, ammonium acetate and 8-hydroxy-7-iodoquinoline-5-sulfonic acid (HISA) as the catalyst under microwave irradiation in mild reaction conditions to synthesis some of 2,4,5-triarylsubstituted imidazole derivatives. The present method is excellent yields, eco-friendly, shorter reaction time, inexpensive and readily available catalyst.