Letrezole or clomide for ovulation induction in patients with unexplained infertility.

Abstract

: Background: The aim of our study to compare the efficacy of letrezole to clomiphene citrate in patient with unexplained infertility as empirical treatment. Methods: 200 patients with unexplained infertility randomly divided into two groups the first group received( 5mg letrezole from the day 3-7 of menstrual cycle), the second group received (100 mg clomiphene citrate from the day 2-5 of menstrual cycle), follicular development followed by serial U/S, when one or more follicles reach > 18mm in diameter ovulation trigger by hCG and timed intercourse was advise later on . Pregnancy test was performed 5 days after the miss period to confirm the pregnancy, the main outcome was the pregnancy rate and the secondary outcome was follicle development and endometrial thickness. Result: Both groups comparable HCG