Investigation of Potential Inhibitors of Brown Adipose Tissue Induced Thermogenesis

Abstract

Obesity is a worldwide problem that causes damage to quality of life and the national health care system. There is no effective treatment for obesity, and the development of novel treatment is necessary. Thermogenesis is a process that happens in thermogenic adipose tissue by transferring energy storage into heat and is a potential target for obesity treatment. In this paper, I screened for potential thermogenic inhibitors by cross comparing human and mouse unbiased proteomic profiling to get 3 out of 7 potential inhibitors. By designing genetic engineering approaches, I acquired gain-of-function and loss-of-function tools for further molecular biology regulation studies of my candidates