Botulinum Toxins

Massimo Signorini, A. Carruthers, Laura Bertolasi, N. Sadick, W. Philipp-Dormston, D. Bertossi
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Abstract

Botulinum Toxin Type A Based on review of available data, the Company may consider the use of botulinum toxin Type A products (Botox, Dysport, or Xeomin) to be eligible for coverage** for any of the following conditions: • Strabismus ∞ • Blepharospasm or facial nerve (VII) disorders (including hemifacial spasm) ∞ • Cervical dystonia (spasmodic torticollis; applicable whether congenital, due to child birth injury, or traumatic injury). For this use, cervical dystonia must be associated with sustained head tilt or abnormal posturing with limited range of motion in the neck AND a history of recurrent involuntary contraction of one or more of the muscles of the neck, e.g., sternocleidomastoid, splenius, trapezius, or posterior cervical muscles ∞ • Upper limb spasticity ∞ • Lower limb spasticity ∞ • Axillary hyperhidrosis that is inadequately managed with topical agents ∞ • Urinary incontinence due to detrusor overactivity associated with a neurologic condition (e.g., Spinal Cord Injury, Multiple Sclerosis) in patients who have an inadequate response to or are intolerant of an anticholinergic medication ∞ • Overactive bladder (OAB) in adults unresponsive to or intolerant of an anticholinergic medication ∞ • Chronic migraine headaches ∞:
肉毒毒素
A型肉毒毒素基于对现有数据的审查,公司可能会考虑使用A型肉毒毒素产品(Botox、Dysport或Xeomin)以符合以下任何情况的覆盖**:斜视、眼睑痉挛或面神经(VII)疾病(包括面肌痉挛)、颈肌张力障碍(痉挛性斜颈;适用于先天性,由于孩子出生伤害,或创伤性伤害)。对于这种用法,颈肌张力障碍必须伴有持续的头部倾斜或颈部活动范围有限的异常姿势,以及颈部的一块或多块肌肉(如胸锁乳突肌、脾肌、斜方肌)反复不自主收缩的病史。或颈后肌∞•上肢痉挛∞•下肢痉挛∞•外用药物治疗不当的腋窝多汗症∞•与神经系统疾病(如脊髓损伤)相关的逼尿肌过度活动导致的尿失禁;对抗胆碱能药物反应不充分或不耐受的多发性硬化症患者;对抗胆碱能药物无反应或不耐受的成人膀胱过动症(OAB);慢性偏头痛;
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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