Differences in Immune Checkpoint Protein Expression among Immune Cells in Lung Carcinoma

Abstract

Lung adenocarcinoma is one of the most common types of lung cancer. Tumour-infiltrating lymphocytes (TILs) play an important role in the immune surveillance in lung cancer. In this study, we addressed the differences among TILs in lung cancer of different stages. For this, we re-analysed publicly available single-cell RNA sequencing (scRNA-Seq) datasets from patients with lung adenocarcinoma. By comparing the expression of immune checkpoint proteins in TILs from patients with different lung cancer stages, we found that TILs differ in the expression of immune checkpoint proteins. This difference is related to the TIL subtype and cancer stage.