Secretory autophagy maintains proteostasis upon lysosome inhibition

T. Solvik, Tan A Nguyen, Yu-Hsiu Tony Lin, Timothy Marsh, E. Huang, A. Wiita, Jayanta Debnath, Andrew M. Leidal
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引用次数: 46

Abstract

Solvik et al. reveal that the autophagy machinery facilitates the secretion of autophagy cargo receptors and other cellular components via extracellular vesicles and particles in response to lysosome inhibition or impaired autophagosome maturation.
分泌性自噬在溶酶体抑制下维持蛋白静止
Solvik等人发现,在溶酶体抑制或自噬体成熟受损的情况下,自噬机制通过细胞外囊泡和颗粒促进自噬货物受体和其他细胞成分的分泌。
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