Discrepant cortisol values: comparison of radioimmunoassay and competitive protein binding technics.

Behavioral neuropsychiatry Pub Date : 1976-04-01
T S Danowski, S M Robinson, E R Fisher, P Antolik
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Abstract

Radioimmunoassays are expected to yield values representing the antigen, i.e., insulin, growth, cortisol, etc. employed in producing the antibody. However, in a recent study of a synthetic ACTH which involved the measurement of cortisol levels (1), we found that above 20gamma%, the radioimmunoassay (RIA) yields cortisol values distinctly above those obtained with the competitive protein binding (CPB) technic. We now suggest a possible explanation for this discrepancy and have calculated a correction factor.

不同的皮质醇值:放射免疫测定和竞争性蛋白质结合技术的比较。
放射免疫测定期望产生代表抗原的值,即用于产生抗体的胰岛素、生长、皮质醇等。然而,在最近一项涉及皮质醇水平测量的合成ACTH的研究中(1),我们发现放射免疫测定(RIA)产生的皮质醇值高于20gamma%,明显高于竞争蛋白结合(CPB)技术获得的皮质醇值。我们现在对这种差异提出一种可能的解释,并计算出一个修正系数。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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