A Review on the Techniques for Early Diagnosis of Alzheimer’s Disease

M. Shahzadi, Bareera Saeed, Muhammad Azzam Khan, Amna Rashid, Muhammad Bilal, Roma Imtiaz, T. Faridi
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Abstract

Alzheimer’s disease is a neurological condition in which there is rapid deterioration of the brain and it affects around 50 million people globally. The most obvious sign of Alzheimer’s is dementia which is primarily an affliction of old age. Majority of the people presenting with dementia in old age are Alzheimer’s patients. The symptoms of Alzheimer’s disease are debilitating and have the ability to utterly disrupt a person's normal life. It is only discovered after this terrible disease has destroyed all neurons, thus there is little chance to cure it or reverse the adverse effects. There are two types of techniques for detecting Alzheimer's disease: invasive and non-invasive techniques. Invasive method obtains data from the patient bydrawing a small amount of blood or performing a lumbar puncture, whereas noninvasive method collects data using imaging techniques like MRI and CT scan. Invasive technique, on the other hand, is thought to be a more accurate indicator of Alzheimer's disease than non-invasive technique since it provides strong biomarkers. Once Alzheimer's disease has progressed to its final stage, it is incurable. Treatment is only viable when the disease is in its initial stages. Future treatments for Alzheimer's disease will focus on the causative maladies of neurofibrillary tangles (ptau) and senile plaques (A). The pathological traits connected to debilitating disease, special protein, b proteins, are critical for future therapeutics
阿尔茨海默病早期诊断技术综述
阿尔茨海默病是一种神经系统疾病,会导致大脑迅速退化,全球约有5000万人受到影响。阿尔茨海默氏症最明显的症状是痴呆症,这主要是老年人的痛苦。大多数老年痴呆症患者都是阿尔茨海默氏症患者。阿尔茨海默病的症状使人衰弱,并有能力完全扰乱一个人的正常生活。只有在这种可怕的疾病破坏了所有的神经元后才会发现,因此几乎没有机会治愈它或扭转不良影响。有两种检测阿尔茨海默病的技术:侵入性和非侵入性技术。有创性方法通过抽取少量血液或腰椎穿刺从患者身上获取数据,而无创性方法通过MRI和CT扫描等成像技术收集数据。另一方面,侵入性技术被认为是比非侵入性技术更准确的阿尔茨海默病指标,因为它提供了强大的生物标志物。一旦阿尔茨海默病发展到最后阶段,就无法治愈了。只有当疾病处于初期阶段时,治疗才可行。阿尔茨海默病的未来治疗将集中在神经原纤维缠结(ptau)和老年斑(A)的致病疾病上。与衰弱性疾病相关的病理特征,特殊蛋白,b蛋白,对未来的治疗至关重要
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