Gastrointestinal stromal tumor – A systemic review literature

Abstract

Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors of the gastrointestinal tract and originate from the interstitial cells of Cajal. They arise most commonly from the stomach or small intestine, with a median age of 60 years. We did not find any relationship between GIST and ABO blood group and Rh factor. Mutations in KIT exon 11 are found to be more common in larger tumors, and the presence of this mutation has been shown to have an adverse prognostic influence. Deletions compared with point mutations in exon 11 have also been found to be a significant unfavorable factor in patients with gastric GISTs. The study group includes all cases of GIST and extra-GIST. Review literatures were taken from Internet Google search and some websites of high index journals. The data extruded mainly were sites of the gastrointestinal tract, histological types, different immunohistochemical markers, etc., Stomach is the most common site of GIST around 70%. Spindle cell is the most common histological variety; CD117 is frequently found immunohistochemical finding. From the abovementioned results, we can easily come to the diagnosis of specific type of GIST and its respective therapeutic measures.