A Minimally Invasive Flexible Micro-Needle Array as Continuous in vivo Electrochemical Glucose Sensor

Abstract

We demonstrate a novel minimally invasive flexible sensor for continuous in vivo glucose monitoring. This sensor is based on a gold-coated polyimide microneedle array (MNA) electrode, which is modified with glucose oxidase. Owing to the spiky micro-needles, flexible substrate, and biocompatible materials, the enzymatic surface is able to penetrate the outer skin, and directly detect the subcutaneous glucose with high biosafety. The current results show that our device performs good response, linearity, and stability to the change of glucose concentration.