Role of Bioinformatics in Identifying Potential Biomarkers of Cervical Cancer

Abstract

Cervical cancer is the one of the leading causes of death among women worldwide. The cancer evolves over a longer period of time and can be screened by different laboratory tests. In developed countries although the rate of incidence and mortality has been reduced, in developing countries the incidence rate still remains high. A large number of factors have been reported that promote the risk of cervical cancer. Some host factors play crucial role in the induction of the malignant transformation. These include micro RNAs that have known to act as oncogenes or tumor suppressor genes in tumors of cervical cancer. Certain high throughput technologies have generated data on miRNAs that are significant in the pathogenesis of cervical cancer. The data has been investigated extensively with the help of tools of bioinformatics for identification of potential biomarkers of cervical cancer. In the current article, we aim to discuss the properties of the tools of bioinformatics that have paved the research on cervical cancer. It is concluded that there is a need of development of large number and various types of tools of bioinformatics facilitating identification of potential biomarkers of cervical cancer for early diagnosis and better treatment regimen.