POST-ACUTE SEQUELAE OF COVID-19. THE PATHOPHYSIOLOGY, RISKS, BIOMARKERS, DIAGNOSIS, AND PROGNOSIS

Abstract

The paper refers the outcomes of international research in post-acute sequelae of COVID-19 (PASC). It is necessary to emphasize the pathophysiological mechanisms of PASC in PCR-negative patients recovered from COVID-19: long-persistent hyperactivated congenital immunity, hyper-inflammation, hyper-coagulation, hypo-fibrinolysis, micro-thrombosis, antibodies formation, and multiplе human organ dysfunction. The challenges as well as possibilities in laboratory diagnostics of PASC complication have been noted.