Cocaine use and related pathologies

Abstract

The use of cocaine, which is a stimulant substance that can quickly develop addiction, is increasing in Europe and Turkey. Cocaine use can cause psychiatric and physical diseases in the individual, but it can also cause social and legal problems. Genetic, sociocultural and pharmacological factors, some factors related to learning and conditioning have an important role in the etiology of cocaine addiction. Cocaine exerts its psychoactive and addictive effects through the limbic system in the brain, which regulates pleasure and motivation. The nucleus accumbens, which is a part of the limbic system, is the most important region that mediates the effect of cocaine. Cocaine use can often be seen together with other psychiatric diseases, and it can also cause damage by affecting other system organs, especially the central nervous system. In this article, the neurochemical effects of cocaine, related psychiatric/physical diseases and treatment options are presented in the light of current information.