Dual Signaling Modes of Alpha7 Nicotinic Acetylcholine Receptors (α7 nAChRs)

Abstract

This themed section of the Annals of Experimental and Molecular Biology is the product of an article that is focusing on metabotropic signaling of an ionotropic channel alpha7 nicotinic ACh receptors (α7 nAChRs). The article talks about how α7 nAChR, being an ion channel, can function in a metabotropic-signaling mode via Gprotein coupling followed by Gαq-PLC-IP3-Ca2+ release