The correlation of exhaled nitric oxide, atopy, and severity of allergic rhinitis in taiwanese children with moderate persistent asthma

Pediatric Respirology and Critical Care Medicine Pub Date : 2017-01-01 DOI:10.4103/PRCM.PRCM_12_16

Yu-Ting Yu, S. Shyur, S. Chu, Yu-Hsuan Kao, H. Lung, Wei‐Te Lei, Li-Ching Fang, Chien-Hui Yang

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Abstract

Background: Allergic rhinitis (AR) is characterized by eosinophilic infiltration and immunoglobulin E (IgE)-mediated reaction after exposure to an allergen. Its severity may be correlated to fractional exhaled nitric oxide (FeNO). This study aimed to evaluate the correlation of FeNO and various parameters with severity of AR in Taiwanese children with moderate persistent asthma. Materials and Methods: The study enrolled 103 children aged 5–18 years with AR and moderate persistent asthma from the Outpatient Department, Mackay Memorial Hospital, Taipei. Based on Total Nasal Symptom Score (TNSS), the patients were divided into high-score group (TNSS ≥5) and low-score group (TNSS <5). Both groups were assessed and compared by FeNO, blood eosinophil percentage, serum total IgE level, specific IgE levels to 8 allergens, and pulmonary function tests. Results: The low-score group showed significantly lower FeNO (18.57 ± 14.47 vs. 26.83 ± 17.84 ppb; P < 0.05), lower blood eosinophil percentage (3.08 ± 3.43 vs. 4.53 ± 3.37%; P < 0.05), lower level of serum total IgE (232.64 ± 438.88 vs. 510.63 ± 732.64 IU/mL; P < 0.05), and lower specific IgE to Dermatophagoides pteronyssinus (Der p), Dermatophagoides farinae (Der f), and dog (1.80 ± 2.35 vs. 3.66 ± 2.23, P < 0.05; 1.78 ± 2.36 vs. 3.56 ± 2.31, P < 0.05; and 0.00 ± 0.00 vs. 0.29 ± 0.81, P < 0.05). There are no significant differences between two groups about forced expiratory volume in 1 s (FEV1) (96.95 ± 13.39 vs. 97.85 ± 14.98% predicted; P = 0.75), FEV1/forced vital capacity percentage (89.00 ± 9.78 vs. 90.20 ± 5.85%; P = 0.47), and forced expiratory flow 25%–75% (55.16 ± 18.48 vs. 56.75 ± 20.15% predicted; P = 0.68). Conclusions: Taiwanese children with moderate persistent asthma with more severe symptoms of AR are significantly associated with higher levels of FeNO, total IgE, specific IgE to Der p, Der f, and dog, and higher blood eosinophil percentage.

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台湾中度持续性气喘患儿呼出一氧化氮、特应性与变应性鼻炎严重程度之关系

背景:变应性鼻炎(AR)的特征是接触过敏原后嗜酸性粒细胞浸润和免疫球蛋白E (IgE)介导的反应。其严重程度可能与呼出一氧化氮(FeNO)分数有关。本研究旨在探讨台湾中度持续性哮喘患儿的FeNO及各项指标与AR严重程度的相关性。材料与方法:本研究入组103名来自台北麦凯纪念医院门诊部的5-18岁AR合并中度持续性哮喘患儿。根据总鼻症状评分(TNSS)将患者分为高评分组(TNSS≥5)和低评分组(TNSS <5)。两组通过FeNO、血嗜酸性粒细胞百分比、血清总IgE水平、对8种过敏原的特异性IgE水平和肺功能测试进行评估和比较。结果:低评分组FeNO明显低于对照组(18.57±14.47 vs. 26.83±17.84 ppb);P < 0.05)，血嗜酸性粒细胞百分比降低(3.08±3.43∶4.53±3.37%;P < 0.05)，血清总IgE水平较低(232.64±438.88∶510.63±732.64 IU/mL;P < 0.05)，且对翼状棘球绦虫(Der P)、粉状棘球绦虫(Der f)和狗的特异性IgE较低(1.80±2.35∶3.66±2.23,P < 0.05);(1.78±2.36)∶(3.56±2.31)，P < 0.05;0.00±0.00 vs. 0.29±0.81,P < 0.05)。两组患者1 s内用力呼气量(FEV1)预测值(96.95±13.39 vs. 97.85±14.98%)差异无统计学意义;P = 0.75)， FEV1/强迫肺活量百分比(89.00±9.78∶90.20±5.85%;P = 0.47)，用力呼气流量预测值为25% ~ 75%(55.16±18.48比56.75±20.15%;P = 0.68)。结论:台湾中度持续性哮喘患儿伴较严重AR症状者，其FeNO、总IgE、对Der p、Der f和犬的特异性IgE水平及血嗜酸性粒细胞百分比升高均显著相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Pediatric Respirology and Critical Care Medicine

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