[Effects of adrenalectomy and cortisol administration on the concentration of free fatty acids, triglycerides and total lipids on the liver of rats].

Revista iberica de endocrinologia Pub Date : 1976-07-01
J M De Gandarias, M Lacort, B Fernández, S Rabanal, F Ainz, J M Pamo, J J Goiriena de Gandarias
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Abstract

The hepatic concentration of triglycerides, free fatty acids and total lipids was determined in four groups of rats: normals, adrenectomized and normal and adrenectomized previously treated with cortisol, 30 mg. In chronic adrenectomized state, total lipids and hepatic triglycerides are diminished, particularly the triglycerides. Adrenectomy does not appear to have significative effect on the free fatty acids. The administration of cortisol does not change those observations and, when given to normal animals, decreases the hepatic concentrations of free fatty acids, triglycerides and total lipids.

[肾上腺切除术和皮质醇给药对大鼠肝脏游离脂肪酸、甘油三酯和总脂浓度的影响]。
测定四组大鼠肝脏中甘油三酯、游离脂肪酸和总脂质浓度:正常、去肾上腺和去肾上腺后给予皮质醇30 mg。慢性肾上腺切除术时,总脂质和肝脏甘油三酯降低,尤其是甘油三酯降低。肾上腺切除术似乎对游离脂肪酸没有显著影响。皮质醇的施用不会改变这些观察结果,并且当给予正常动物时,会降低肝脏游离脂肪酸,甘油三酯和总脂质浓度。
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