Pathway-Based Microarray Analysis for Defining Statistical Significant Phenotype-Related Pathways: A Review of Common Approaches

Abstract

In this review, we have discussed about approaches in pathway based microarray analysis. Commonly, there are two approaches in pathway based analysis, Enrichment  Score and Supervised Machine Learning. These pathway based approaches usually aim to statistically define significant pathways that related to phenotypes of interest. Firstly we discussed an overview of pathway based microarray analysis and its general flow processes in scoring the pathways, the methods applied in both approaches, advantages and limitations  based on current researches, and pathways database used in pathway analysis. This review aim to provide better understanding about pathway based microarray analysis and its approaches.