In vitro effect of serum IgGs with oxidoreductase activities of schizophrenic patients on apoptosis level

Abstract

This paper presents the results of a study of the effect of IgG with catalase and superoxide dismutase activities, isolated from the blood serum of patients with paranoid schizophrenia, on the parameters of apoptotic cell death in an in vitro experiment, using a model of the SH-SY5Y human neuroblastoma cell line. The catalase and superoxide dismutase activities of immunoglobulins G were evaluated, and these activities were proved to belong to antibodies. It has been shown for the first time that abzymes from patients with schizophrenia in the therapeutic remission phase significantly reduce the level of apoptosis in the SH-SY5Y human neuroblastoma cell line after 24 incubations in an in vitro experiment.