CHARACTERISATION AND SPECIFIC MARKERS EXPRESSION OF SOFT TISSUE SARCOMA: CASE REPORTS FOR THE DOG AT THE HO CHI MINH CITY VETERINARY CLINIC

Abstract

Treatment failure in removing canine soft tissue tumors, a locally invasive mesenchymal neoplasm, may occur in between 7 and 75 percent of patients, with recurrence consistently associated with lower overall survival for the dog. This study was to classify the tumor examine the occurrence of cancers in dogs reported at the Ho Chi Minh Veterinary Clinic by integrating blood physiological and histopathological of patient samples. In this study, the percentage of tissue sarcoma in the dog was 1.5%. Histopathological analysis characteristics of the ear lobe tumors displayed a strong proliferation of rhabdoid cells, presence of leukocytes infiltrating around blood vessels, and vaginal tumors showed normal tumor cell density with a strong collagen fibers formation in fibroblast cells and no strong proliferation and ferocity of cells. In particular, immuno-histopathological analysis of biopsies sample from breast tumor showed an overexpressing of vimentin marker (68.1%) in cells which indicated status of malignant metastasis. The metastatic tumor cells in breast tumor might cause the change in blood biochemical parameters together with sepsis, thus the dog was not eligible for surgery. In general, histological examination and expression levels of markers can help determine the malignant status of tumors in dogs and should be included medical examination to limit local recurrence following surgical resection.