Localization of Herpetic Viruses Patterns in Sinonasal and Nasopharyngeal Malignant and Benign Tumors

Abstract

Nasopharyngeal cancer is a highly malignant tumor, the primary tumor mass can extend within the nasopharynx and/or extend to the base of the skull, palate, nasal cavity or oropharynx and distant metastases can arise in bone, lung, mediastinum and liver [1,2]. Sinonasal carcinoma could arise from various tissues within the nasal cavity, including lymphoreticular, epithelial and nonepithelial tumors [3]. Sinonasal Papillomas are a rare disease which have an annual incidence of 0.6/105 in defined geographical regions. The investigations of these tumors have shaded the light on a viral agent as an etiological candidate, such as EBV [4]. In addition, an outdoor and industrial occupations are the major risk factors for sinonasal Papillomas development [5]. Inflammatory Polyps lesions are affecting 1-4% of all population [6]. Where they arise as an outgrowth from the mucosal membrane of nasal cavity and paranasal sinuses as a result of an allergic or chronic inflammation [7].