A Stepwise Procedure for Toxicity Studies Based on Ratio of two means

Abstract

This paper proposes a stepwise confidence set procedure for identifying equivalence or safety of compounds in a toxicity study under heteroscedasticity of variances for a normally distributed data. The problem of statistical methodology for drug safety is the control of the familywise error rate (FWER). Hence, we construct a confidence set procedure for toxicological evaluation and incorporating the partitioning principle with a case of heteroscedascity of variances under normal assumption. Our simulation studies demonstrated that the power of the procedures for heterogeneity of variances increases with increasing in ratio of means.