Transcranial magnetic stimulation in cognitive neuroscience: Methodological basis and safety

Abstract

Transcranial magnetic stimulation (TMS) is an intensively developing method of non-invasive brain stimulation. TMS is widely used in cognitive neuroscience to study the causal role of various cortical areas in visual perception, memory, attention, speech, and other cognitive functions. The article discusses the general principles and main directions of TMS applications in cognitive research as well as the modern aspects of using online TMS protocols for the creation of a temporary “virtual lesion”, functional brain mapping, and chronometric studies. Possible applications of offline TMS protocols for long-term modulation of the stimulated cortical area activity are also discussed. Methodological features of TMS studies, including targeting methods, as well as the frequency and intensity of stimulation, are highlighted. The article also describes the possibilities of combining TMS with other methods. Finally, the safety aspects of TMS in healthy subjects in the context of cognitive studies are discussed