The closed-loop regulation of blood glucose in diabetics

Abstract

The development of a system for the closed-loop regulation of blood glucose concentration (BGC) in a Type-1 diabetic when sparse measurements of the blood glucose concentration are available is discussed. A model reference technique to provide an estimate of the BGC is implemented. Whenever, a BGC measurement is not available, the BGC estimate is used in the controller realization. After developing the model reference offline, a computer simulation is realized for closed-loop regulation of blood glucose concentration in a Type-1 diabetic. A recursive parameter-estimation scheme is implemented to update the parameters of the model reference throughout the closed-loop simulation. These parameter estimates can be used to adjust some of the controller parameters to enhance the robustness of the controller.<>