Lactate dynamics during circulatory hypoxia. Mathematical model and analysis

Proceedings of the 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 'Magnificent Milestones and Emerging Opportunities in Medical Engineering' (Cat. No.97CH36136) Pub Date : 1997-10-30 DOI:10.1109/IEMBS.1997.758749

M. Cabrera, G. Saidel, S. Kalhan

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Abstract

The mechanistic basis of the relationship between O/sub 2/ and lactate (LA) concentration in muscle are not fully understood. Increases in LA are frequently observed under hypoxic conditions and during high intensity exercise. However, there are other instances in which lactate can accumulate for reasons other than O/sub 2/ limitation. Our aim is to investigate, using a mathematical model and computer simulations, potential regulatory mechanisms affecting the dynamics of LA in various tissues during hypoxic conditions. Simulations of circulatory hypoxia closely predicted the pattern of change in substrates observed experimentally. Model analysis suggests that the rate of lactate production is regulated with high sensitivity through changes in ADP/ATP and NADH/NAD which are induced indirectly by a small drop in the rate of oxygen consumption due to a decrease in muscle O/sub 2/ concentration.

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循环缺氧时的乳酸动力学。数学模型与分析

肌肉中O/sub - 2/与乳酸(LA)浓度之间关系的机制基础尚不完全清楚。在低氧条件下和高强度运动中经常观察到LA的增加。然而，在其他情况下，乳酸可因O/sub /限制以外的原因积累。我们的目的是利用数学模型和计算机模拟来研究在缺氧条件下影响各种组织LA动力学的潜在调节机制。循环缺氧的模拟与实验中观察到的底物变化模式密切相关。模型分析表明，乳酸生成速率是通过ADP/ATP和NADH/NAD的变化进行高灵敏度调节的，而ADP/ATP和NADH/NAD的变化是由肌肉O/sub 2/浓度的降低间接引起的耗氧量的小幅下降。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Proceedings of the 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 'Magnificent Milestones and Emerging Opportunities in Medical Engineering' (Cat. No.97CH36136)

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