Case 71: Small Fiber Neuropathy, Postural Tachycardia, and Mast Cell Activation Syndrome

Abstract

The patient has history of mast cell activation syndrome (MCAS) in which mast cells inappropriately release active substances including leukotriene and histamines, triggering symptoms of flushing and orthostatic intolerance. Small fiber neuropathy was length-dependent, mild, affecting predominantly sensory fibers. Tilt test showed postural tachycardia syndrome (POTS).