The effect of immune complex composition on complement activation and complement dependent complex release

Immunochemistry Pub Date : 1978-12-01 DOI:10.1016/0161-5890(78)90123-2

Eva Rajnavo¨lgyi , G. Fu¨st , Judit Kulics , Julia Ember , G.A. Medgyesi , J. Gergely

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引用次数: 14

Abstract

The complement activating capacity and complement dependent complex release activity (CRA) of immune complexes (IC) formed at different antigen:antibody ratios were investigated. The correlation between antibody avidity, precipitating capacity and the effect of these parameters on Fcdependent biological functions was studied in BSA-anti-BSA and OA-anti-OA systems. The results suggest that antibody excess favours the complement activating effect of ICs. No correlations between antibody precipitating capacity and avidity was found. However, antibody avidity and complement activating capacity were related: the higher the avidity index of antibodies, the higher the complement activation. The kinetics of CRA are not directly influenced by these characteristics of antibodies. The intercalation of C3b into the lattice interferes not only with the primary antigen—antibody bonds, it may result in the rearrangement of the lattice through the disruption of the non-specific intermolecular interactions.

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免疫复合物组成对补体激活和补体依赖性复合物释放的影响

研究了不同抗原抗体比下形成的免疫复合物(IC)的补体激活能力和补体依赖性复合物释放活性(CRA)。在BSA-anti-BSA和OA-anti-OA体系中，研究了抗体亲和度、沉淀能力及其对fc依赖性生物学功能的影响。结果表明，抗体过量有利于ic的补体激活作用。抗体沉淀能力与贪婪度无相关性。抗体亲和度与补体活化能力相关，抗体亲和度指数越高，补体活化能力越高。CRA的动力学不受抗体这些特性的直接影响。将C3b插入晶格中不仅会干扰初级抗原-抗体键，还可能通过破坏非特异性分子间相互作用导致晶格重排。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Immunochemistry

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