Passive cutaneous anaphylactic reactions as tools in the study of the structure of the IgG molecule

Abstract

By use of passive cutaneous anaphylaxis it has been shown that the structure necessary for fixation to tissue constitutents (receptors) is on the Fc fragment. Fc fragments from rabbit IgG can inhibit passive cutaneous anaphylaxis in guinea pigs by competition for the receptor. The fixation of the Fc fragment to receptors (on mastcells) was shown also by reverse passive cutaneous anaphylaxis using dinitrophenylated Fc fragments and anti-dinitrophenyl antibodies.