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Abstract

Overview of the bio-informatics analysis to process the raw LC-MS/MS data into CDR peptide sequences. LS-MS/MS output and peptide sequences fulfilling the criteria specified in the boxes with grey letters were excluded for further analysis. Software packages for data pre-processing and statistical analyses are specified in the blue boxes. Identified CDR peptides (indicated in bold) were used for further statistical analysis: MixOmics (R) and Qlucore Omics Explorer. ALC: Average of Local Confidence.