Karhunen-Loeve-transformation of functional optical imaging of brain activity-consequences and implications

Abstract

Using the Karhunen-Loeve-transformation on sequential images of functional brain activity obtained by optical recording of intrinsic signals we were able to separate different components within the dynamic oximetric response, which are: (1) separate functional representations and vessel artifacts, (2) one component for more consistent local activation could be identified, (3) a second region of more spread activity could be differentiated.