New Information on the Mechanisms Underlying the Neurotoxicity Caused by Methylmercury and Manganese

Abstract

Toxic elements are extensively distributed in the Earth’s crust and individuals may be exposed to several of them. Indeed, exposure to toxic elements such as mercury (Hg) can be a potential health risk factor of health, mainly by ingestion of fish containing methylmercury (MeHg). On the other hand, essential elements such as manganese (Mn) play an important role in physiological process in human body. In this regard, it is well known that MeHg and Manganese have neurotoxic effects on the developing brain. Therefore, we discuss the effects of Methylmercury and Manganese on cell signaling pathways in this review, as these effects may contribute to the molecular mechanisms underlying Methylmercury and Manganese -induced neurotoxicity.