NUMERICAL SIMULATION ON-TIME EVALUATION OF PLASMA DRUG CONCENTRATIONS FOR ONE-COMPARTMENT MODEL IN PRESENCE OF DRUG INFUSION

Abstract

In the present numerical study, we apply an ODE IVP to plasma drug concentrations for a one-compartment model in presence of drug infusion. Solution procedure is done in a Matlab environment. The outcome shows that the infusion rate at time t = 4 h is discontinuous but the corresponding plasma concentration-time profile looks smooth at that time.