Protective and ameliorative role of date palm pollen and vitamin C against gastric toxicity induced by bisphenol-A in male albino rat

Abstract

: This study evaluated the protective and ameliorative role of date palm pollen and vitamin C against bisphenol- A (BPA) induced gastric structure toxicity in rats. Control rats received only food and water. Second group administrated BPA ( 30 mg/kg b.wt. ). Third group was given DPP (100 mg/kg b.wt.).Fourth group was given Vit. C (160 mg/kg b.wt.). Fifth group was given DPP 12 hrs before administration of DPP, while the sixth group was given BPA 12 hrs before administration of BPA. The seventh group was given Vit. C 12 hrs before administration of BPA, whereas the eighth group was given BPA 12 hrs before administration of vit. C. The ninth group was given DPP combined with Vit. C 12 hrs before administration of BPA.BPA induced histopathological changes in the stomach indicated by congestion at the vasculatureand edema of the submucosal layer of the non-glandular part, and congestion of the blood vessels at the muscular layer of the glandular part. However, administration of each DPP and vitamin C before and after BPA, or combined with each other before BPA, restored the normal histological structure of the stomach. So, this study revealed that DPP and Vit. C protected and ameliorated gastric structure against BPA toxicity via their antioxidant activities.