Effect of lycopene on hepatotoxicity induced by perfluorooctane sulfonic acid in rats

Abstract

Objective: Intend to observe the liver injury induced by perfluorooctane sulfonic acid (PFOS) in SD rats and the protective effect of lycopene (LP) and its possible mechanism. Methods: 48 SD rats were randomly divided into 8 groups. The solvent control group of LP protection group and LP protection low, middle and high dose PFOS exposure groups were given LP suspension once a day according to their designed dose. The contents of ALT, ASP and AST in serum, the content of MDA in liver tissue and the activity of SOD and GSH-Px in liver tissue were measured after 2 months. Results: The levels of serum ALT, AST and serum ASP enzyme activity in middle and high dose PFOS groups and high dose PFOS groups were significantly higher than those in solvent control group (P