Dye-enhanced multispectral transillumination for breast cancer detection: feasibility measurements

Proceedings of the 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 'Magnificent Milestones and Emerging Opportunities in Medical Engineering' (Cat. No.97CH36136) Pub Date : 1997-10-30 DOI:10.1109/IEMBS.1997.757721

M. Braunstein, R. Chan, R. Levine

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引用次数: 3

Abstract

Near-IR transillumination for breast cancer detection is limited by poor discrimination among different breast conditions; including the presence of cancerous, benign, and fibrous tissues. Perhaps due to enhanced vascularity, there is evidence that a contrast agent, indocyanine green (ICG), accumulates at the site of malignant tumors. The 805 nm absorption edge of the compound suggests that multispectral transillumination, coupled with special-purpose data fusion processing, could enhance the discrimination of tumors. In this paper we report on the transillumination of in-vitro tissue samples in which minute (<10 /spl mu/gm) quantities of ICG have been injected. Discrimination and deblurring algorithms fusing multispectral images in the range 750-1000 nm are applied to enhance detectability of the ICG in tissue.

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染料增强多光谱透照用于乳腺癌检测:可行性测量

近红外透照检测乳腺癌的局限性在于不同乳腺状况的鉴别能力差;包括癌组织、良性组织和纤维组织的存在。可能由于血管增强，有证据表明造影剂吲哚菁绿(ICG)在恶性肿瘤部位积聚。该化合物805 nm的吸收边缘表明，多光谱透照结合专用数据融合处理可以增强肿瘤的识别能力。在本文中，我们报道了在体外组织样品中注射微量(<10 /spl mu/gm) ICG的透照。采用750 ~ 1000 nm范围内多光谱图像融合的判别和去模糊算法，提高组织中ICG的可检测性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Proceedings of the 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 'Magnificent Milestones and Emerging Opportunities in Medical Engineering' (Cat. No.97CH36136)

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