Probing the Binding of Two Antibiotics to Human – Holo Transferrin: A Combined Spectroscopic and Docking study.

S. Bakkialakshmi, T. Anupriya
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Abstract

Ciprofloxacin (CPFX) and Tetracycline (TC) are two of the most widely used antibiotics in human and veterinary medicines. Their existence in the environment has experienced much attention because of the potential adverse effects on humans and ecosystem functions. In this paper, the interaction mechanism between the two antibiotics and Human holo transferrin by spectroscopic and molecular docking methods. The distance r, between the antibiotics and the protein was obtained according to FRET which pointed at a successful formation of a drug – protein complex. Molecular docking study provided possible binding sites of antibiotics within the proteins. The obtained data can be convenient for determining usage drug doses in drug delivery.
两种抗生素与人全息转铁蛋白的结合:光谱与对接的联合研究。
环丙沙星(CPFX)和四环素(TC)是人类和兽药中使用最广泛的两种抗生素。由于对人类和生态系统功能的潜在不利影响,它们在环境中的存在受到了广泛关注。本文通过光谱和分子对接的方法对两种抗生素与人全转铁蛋白的相互作用机制进行了研究。根据FRET获得了抗生素与蛋白质之间的距离r,这表明药物-蛋白质复合物的成功形成。分子对接研究提供了抗生素在蛋白内可能的结合位点。所得数据可方便地确定给药过程中的用药剂量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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