Nibrin Double Strand Breakage and its Role in Development of Cancers

Abstract

and the Homologous repair pathway, In non homologous The human genetic information has been orchestrated by DNA-damage response pathways. DNA damage response, DNA repair,programmed apoptosis and cell cycle progession are responsible for maintaining the genomic integrity, they initiates the process of tumorigenesis if they are not regulated properly.An article research was done through Google Scholar, Pubmed and was used for an electronic search of articles, using the following keywords: Double stranded breakage, Nibrin, P95, NBS1.The aim of the review is to point out the impact of double strand breakage and the role of Nibrin in development of cancers. The double strand breakage are pathological insults for all the microorganisms because they can cause the elimination of the essential genetic information, which results in the destruction of DNA replication Nibrin is the first DNA repair gene whose overexpression can promotes the process of tumorigenesis by the activation of phosphoinositol 3 kinase /akt pathways.