Quantitative YAP-(S)PET small animal scanner: preliminary results

2001 IEEE Nuclear Science Symposium Conference Record (Cat. No.01CH37310) Pub Date : 2001-11-04 DOI:10.1109/NSSMIC.2001.1008639

G. Di Domenico, G. Zavattini, E. Moretti, A. Piffanelli, M. Giganti, A. Motta, N. Sabba, L. Uccelli, E. Benini, A. Duatti, C. Bolzati, A. Boschi, A. Del Guerra

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引用次数: 1

Abstract

We have successfully built and characterized small animal PET scanner based on 4 rotating planar detector heads. Each detector module is composed of a matrix of 400 YAP:Ce finger crystals (2/spl times/2/spl times/30 mm/sup 3/ each) directly coupled to position sensitive photomultipliers (Hamamatsu R2486-06). By applying two high resolution collimators to two opposite detectors we realised an integrated PET-SPECT scanner for small animals. At present, at the Department of Experimental and Clinical Medicine of the University of Ferrara, the scanner is employed in small animal SPECT studies with /sup 99m/Tc labeled radiotracers dedicated to obtain quantitative activity measurement in region of interest (ROI) directly from a reconstructed image of a in-vivo rat, with respect to the traditional ex-vivo measurement of activity with gamma counters. To achieve this goal, the scanner was calibrated referring it to a Isodose dose calibrator based on Geiger-Muller counters which previously underwent an absolute calibration with a known activity source. Preliminary results on quantitative tomographic heart perfusion and planar heart biokinetics studies are reported.

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定量YAP-(S)PET小动物扫描仪:初步结果

我们成功地构建了基于4个旋转平面探测头的小动物PET扫描仪并对其进行了表征。每个探测器模块由400个YAP:Ce手指晶体(2/spl倍/2/spl倍/30 mm/sup 3/每个)的矩阵组成，直接耦合到位置敏感的光电倍增管(Hamamatsu R2486-06)。通过将两个高分辨率准直器应用于两个相对的探测器，我们实现了一个集成的PET-SPECT小动物扫描仪。目前，在费拉拉大学实验和临床医学系，该扫描仪被用于小动物SPECT研究，使用/sup 99m/Tc标记的放射性示踪剂，直接从活体大鼠的重建图像中获得感兴趣区域(ROI)的定量活性测量，而不是传统的使用伽马计数器的离体活性测量。为了实现这一目标，将扫描仪与基于盖革-穆勒计数器的等剂量剂量校准器进行校准，该剂量校准器先前使用已知活度源进行了绝对校准。本文报道了心脏灌注定量层析成像和平面心脏生物动力学研究的初步结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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2001 IEEE Nuclear Science Symposium Conference Record (Cat. No.01CH37310)

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