J. Lichtenberg, Mohit Alam, Thomas Bitterman, Frank Drews, Klaus H. Ecker, L. Elnitski, S. Evans, Matt Geisler, E. Grotewold, Dazhang Gu, E. Jacox, K. Kurz, Stephen Lee, Xiaoyu Liang, P. Majmudar, Paul Morris, Chase W. Nelson, E. Stockinger, Joshua D. Welch, S. Wyatt, Alper Yilmaz, L. Welch
{"title":"Construction of Genomic Regulatory Encyclopedias: Strategies and Case Studies","authors":"J. Lichtenberg, Mohit Alam, Thomas Bitterman, Frank Drews, Klaus H. Ecker, L. Elnitski, S. Evans, Matt Geisler, E. Grotewold, Dazhang Gu, E. Jacox, K. Kurz, Stephen Lee, Xiaoyu Liang, P. Majmudar, Paul Morris, Chase W. Nelson, E. Stockinger, Joshua D. Welch, S. Wyatt, Alper Yilmaz, L. Welch","doi":"10.1109/OCCBIO.2009.9","DOIUrl":null,"url":null,"abstract":"Encyclopedias of regulatory genomic elements provide a foundation for research in areas such as disease diagnosis, disease treatment, and crop enhancement. The construction of complete encyclopedias of organism-specific genomic elements involved in gene regulation remains a significant challenge. To address this problem, the authors present novel bioinformatics strategies for exploring the word landscapes of putative regulatory regions of genomes. The methods are incorporated into the WordSeeker software tool, which is available at http://word-seeker.org. The effectiveness of these strategies is demonstrated through several case studies.","PeriodicalId":231499,"journal":{"name":"2009 Ohio Collaborative Conference on Bioinformatics","volume":"45 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2009-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"2009 Ohio Collaborative Conference on Bioinformatics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/OCCBIO.2009.9","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Encyclopedias of regulatory genomic elements provide a foundation for research in areas such as disease diagnosis, disease treatment, and crop enhancement. The construction of complete encyclopedias of organism-specific genomic elements involved in gene regulation remains a significant challenge. To address this problem, the authors present novel bioinformatics strategies for exploring the word landscapes of putative regulatory regions of genomes. The methods are incorporated into the WordSeeker software tool, which is available at http://word-seeker.org. The effectiveness of these strategies is demonstrated through several case studies.
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